Abstract

Review Article

Monkeypox Virus, A Global Public Health Concern and Challenge for Low-income Countries including Pakistan: A Right Time to Nip the Evil in the Bud

Zahra Zahid Piracha, Haider Ali, Noor ul Huda Rasheed, Umar Saeed*, Syed Shayan Gilani, Umer Ali Abbasi, Qasim Khan, Elyeen Noor and Seneen Noor

Published: 13 October, 2023 | Volume 7 - Issue 2 | Pages: 014-019

Monkeypox is a rare zoonotic infection originating in the regions of Central and West Africa. The global threat has been arising since monkeypox is spreading outside of the endemic regions. Pakistan has recently exhausted health funds in a quarrel against SARS-CoV-2, by supplying expensive COVID-19 vaccines to the general public, free of cost. Pakistan’s government has remarkably contributed to lowering the suffering of COVID-19-affected patients by granting the Sehat Sahulat Programme and similar health initiatives to restrict viral propagation in the general public. However, despite all efforts the major constraints are a lack of international funds and limitations on the budget of healthcare systems and medical facilities. Newly emerged cases of monkeypox are very threatening to Pakistan’s economy and health. Therefore, it is very necessary that healthcare authorities take effective measures like surveillance, early identification, separation, monitoring of contacts, immunization, and public awareness in order to stop the spread of the virus and control monkeypox outbreaks.

Read Full Article HTML DOI: 10.29328/journal.ijcv.1001055 Cite this Article Read Full Article PDF

Keywords:

Monkeypox; Pakistan; Health system; Surveillance; Epidemics

References

  1. Jaiswal V, Nain P, Mukherjee D, Joshi A, Savaliya M, Ishak A, Batra N, Maroo D, Verma D. Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID-19 era: A systematic-review. Immun Inflamm Dis. 2022 Nov;10(11):e722. doi: 10.1002/iid3.722. Erratum in: Immun Inflamm Dis. 2023 Jan;11(1):e774. PMID: 36301040; PMCID: PMC9552975.
  2. Cho CT, Wenner HA. Monkeypox virus. Bacteriol Rev. 1973 Mar;37(1):1-18. doi: 10.1128/br.37.1.1-18.1973. PMID: 4349404; PMCID: PMC413801.
  3. Ladnyj ID, Ziegler P, Kima E. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull World Health Organ. 1972;46(5):593-7. PMID: 4340218; PMCID: PMC2480792.
  4. Breman JG, Kalisa-Ruti, Steniowski MV, Zanotto E, Gromyko AI, Arita I. Human monkeypox, 1970-79. Bull World Health Organ. 1980;58(2):165-82. PMID: 6249508; PMCID: PMC2395797.
  5. Chandran D, Dhama K, Chakraborty S, Mohapatra RK, Yatoo MI. Monkeypox: An Update on Current Knowledge and Research Advances. J. Biol. Agric. Sci. 2022; 10:679-688.
  6. McCollum AM, Damon IK. Human monkeypox. Clin Infect Dis. 2014 Jan;58(2):260-7. doi: 10.1093/cid/cit703. Epub 2013 Oct 24. Erratum in: Clin Infect Dis. 2014 Jun;58(12):1792. PMID: 24158414.
  7. Jezek Z, Szczeniowski M, Paluku KM, Mutombo M. Human monkeypox: clinical features of 282 patients. J Infect Dis. 1987 Aug;156(2):293-8. doi: 10.1093/infdis/156.2.293. PMID: 3036967.
  8. Reynolds MG, Davidson WB, Curns AT, Conover CS, Huhn G, Davis JP, Wegner M, Croft DR, Newman A, Obiesie NN, Hansen GR, Hays PL, Pontones P, Beard B, Teclaw R, Howell JF, Braden Z, Holman RC, Karem KL, Damon IK. Spectrum of infection and risk factors for human monkeypox, United States, 2003. Emerg Infect Dis. 2007 Sep;13(9):1332-9. doi: 10.3201/eid1309.070175. PMID: 18252104; PMCID: PMC2857287.
  9. Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, Monroe B, Doty J, Kalemba L, Malekani J, Kabamba J, Bomponda PL, Lokota JI, Balilo MP, Likafi T, Lushima RS, Tamfum JJ, Okitolonda EW, McCollum AM, Reynolds MG. Introduction of Monkeypox into a Community and Household: Risk Factors and Zoonotic Reservoirs in the Democratic Republic of the Congo. Am J Trop Med Hyg. 2015 Aug;93(2):410-5. doi: 10.4269/ajtmh.15-0168. Epub 2015 May 26. PMID: 26013374; PMCID: PMC4530773.
  10. Dashraath P, Nielsen-Saines K, Rimoin A, Mattar CNZ, Panchaud A, Baud D. Monkeypox in pregnancy: virology, clinical presentation, and obstetric management. Am J Obstet Gynecol. 2022 Dec;227(6):849-861.e7. doi: 10.1016/j.ajog.2022.08.017. Epub 2022 Aug 17. PMID: 35985514; PMCID: PMC9534101.
  11. D'Antonio F, Pagani G, Buca D, Khalil A. Monkeypox infection in pregnancy: a systematic review and metaanalysis. Am J Obstet Gynecol MFM. 2023 Jan;5(1):100747. doi: 10.1016/j.ajogmf.2022.100747. Epub 2022 Sep 9. PMID: 36096413; PMCID: PMC9555294.
  12. Bragazzi NL, Kong JD, Mahroum N, Tsigalou C, Khamisy-Farah R, Converti M, Wu J. Epidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review. J Med Virol. 2023 Jan;95(1):e27931. doi: 10.1002/jmv.27931. Epub 2022 Jun 17. PMID: 35692117.
  13. Vaughan AM, Cenciarelli O, Colombe S, Alves de Sousa L, Fischer N, Gossner CM, Pires J, Scardina G, Aspelund G, Avercenko M, Bengtsson S, Blomquist P, Caraglia A, Chazelle E, Cohen O, Diaz A, Dillon C, Dontsenko I, Kotkavaara K, Fafangel M, Ferraro F, Firth R, Fonager J, Frank C, Carrasco MG, Gkolfinopoulou K, Grenersen MP, Guzmán Herrador BR, Henczkó J, Hoornenborg E, Igoe D, Ilić M, Jansen K, Janță DG, Johansen TB, Kasradze A, Koch A, Kyncl J, Martins JV, McAuley A, Mellou K, Molnár Z, Mor Z, Mossong J, Novacek A, Orlikova H, Pem Novosel I, Rossi MK, Sadkowska-Todys M, Sawyer C, Schmid D, Sîrbu A, Sondén K, Tarantola A, Tavares M, Thordardottir M, Učakar V, Van Ewijk C, Varjas J, Vergison A, Vivancos R, Zakrzewska K, Pebody R, Haussig JM. A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022. Euro Surveill. 2022 Sep;27(36):2200620. doi: 10.2807/1560-7917.ES.2022.27.36.2200620. PMID: 36082686; PMCID: PMC9461311.
  14. Sejvar JJ, Chowdary Y, Schomogyi M, Stevens J, Patel J, Karem K, Fischer M, Kuehnert MJ, Zaki SR, Paddock CD, Guarner J, Shieh WJ, Patton JL, Bernard N, Li Y, Olson VA, Kline RL, Loparev VN, Schmid DS, Beard B, Regnery RR, Damon IK. Human monkeypox infection: a family cluster in the midwestern United States. J Infect Dis. 2004 Nov 15;190(10):1833-40. doi: 10.1086/425039. Epub 2004 Oct 12. PMID: 15499541.
  15. Ligon BL. Monkeypox: a review of the history and emergence in the Western hemisphere. Semin Pediatr Infect Dis. 2004 Oct;15(4):280-7. doi: 10.1053/j.spid.2004.09.001. PMID: 15494953; PMCID: PMC7129998.
  16. Yinka-Ogunleye A, Aruna O, Dalhat M, Ogoina D, McCollum A, Disu Y, Mamadu I, Akinpelu A, Ahmad A, Burga J, Ndoreraho A, Nkunzimana E, Manneh L, Mohammed A, Adeoye O, Tom-Aba D, Silenou B, Ipadeola O, Saleh M, Adeyemo A, Nwadiutor I, Aworabhi N, Uke P, John D, Wakama P, Reynolds M, Mauldin MR, Doty J, Wilkins K, Musa J, Khalakdina A, Adedeji A, Mba N, Ojo O, Krause G, Ihekweazu C; CDC Monkeypox Outbreak Team. Outbreak of human monkeypox in Nigeria in 2017-18: a clinical and epidemiological report. Lancet Infect Dis. 2019 Aug;19(8):872-879. doi: 10.1016/S1473-3099(19)30294-4. Epub 2019 Jul 5. PMID: 31285143; PMCID: PMC9628943.
  17. Shchelkunov SN, Totmenin AV, Babkin IV, Safronov PF, Ryazankina OI, Petrov NA, Gutorov VV, Uvarova EA, Mikheev MV, Sisler JR, Esposito JJ, Jahrling PB, Moss B, Sandakhchiev LS. Human monkeypox and smallpox viruses: genomic comparison. FEBS Lett. 2001 Nov 30;509(1):66-70. doi: 10.1016/s0014-5793(01)03144-1. PMID: 11734207; PMCID: PMC9533818.
  18. Kugelman JR, Johnston SC, Mulembakani PM, Kisalu N, Lee MS, Koroleva G, McCarthy SE, Gestole MC, Wolfe ND, Fair JN, Schneider BS, Wright LL, Huggins J, Whitehouse CA, Wemakoy EO, Muyembe-Tamfum JJ, Hensley LE, Palacios GF, Rimoin AW. Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerg Infect Dis. 2014 Feb;20(2):232-9. doi: 10.3201/eid2002.130118. PMID: 24457084; PMCID: PMC3901482.
  19. Hughes AL, Irausquin S, Friedman R. The evolutionary biology of poxviruses. Infect Genet Evol. 2010 Jan;10(1):50-9. doi: 10.1016/j.meegid.2009.10.001. Epub 2009 Oct 13. PMID: 19833230; PMCID: PMC2818276.
  20. Seet BT, Johnston JB, Brunetti CR, Barrett JW, Everett H, Cameron C, Sypula J, Nazarian SH, Lucas A, McFadden G. Poxviruses and immune evasion. Annu Rev Immunol. 2003; 21:377-423. doi: 10.1146/annurev.immunol.21.120601.141049. Epub 2001 Dec 19. PMID: 12543935.
  21. Resch W, Hixson KK, Moore RJ, Lipton MS, Moss B. Protein composition of the vaccinia virus mature virion. Virology. 2007 Feb 5;358(1):233-47. doi: 10.1016/j.virol.2006.08.025. Epub 2006 Sep 26. PMID: 17005230.
  22. Manes NP, Estep RD, Mottaz HM, Moore RJ, Clauss TR, Monroe ME, Du X, Adkins JN, Wong SW, Smith RD. Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions. J Proteome Res. 2008 Mar;7(3):960-8. doi: 10.1021/pr070432+. Epub 2008 Jan 19. Erratum in: J Proteome Res. 2013 Jan 4;12(1):546. PMID: 18205298; PMCID: PMC2517256.
  23. Meng X, Schoggins J, Rose L, Cao J, Ploss A, Rice CM, Xiang Y. C7L family of poxvirus host range genes inhibits antiviral activities induced by type I interferons and interferon regulatory factor 1. J Virol. 2012 Apr;86(8):4538-47. doi: 10.1128/JVI.06140-11. Epub 2012 Feb 15. PMID: 22345458; PMCID: PMC3318637.
  24. Roper RL. Characterization of the vaccinia virus A35R protein and its role in virulence. J Virol. 2006 Jan;80(1):306-13. doi: 10.1128/JVI.80.1.306-313.2006. PMID: 16352555; PMCID: PMC1317533.
  25. Yu X, Shi H, Cheng G. Mpox Virus: Its Molecular Evolution and Potential Impact on Viral Epidemiology. Viruses. 2023 Apr 18;15(4):995. doi: 10.3390/v15040995. PMID: 37112975; PMCID: PMC10142743.
  26. Awan HA, Sahito AM, Sukaina M, Khatri G, Waheed S, Sohail F, Hasan MM. Tuberculosis amidst COVID-19 in Pakistan: a massive threat of overlapping crises for the fragile healthcare systems. Epidemiol Infect. 2022 Feb 22; 150:e41. doi: 10.1017/S0950268822000358. PMID: 35190004; PMCID: PMC8886085.
  27. Mehmood Q, Ullah I, Hasan MM, Kazmi SK, Ahmadi A, Lucero-Prisno DE 3rd. COVID-19 vaccine hesitancy: Pakistan struggles to vaccinate its way out of the pandemic. Ther Adv Vaccines Immunother. 2022 Feb 10; 10:25151355221077658. doi: 10.1177/25151355221077658. PMID: 35174312; PMCID: PMC8841903.
  28. Butt MH, Safdar A, Amir A, Zaman M, Ahmad A, Saleem RT, Misbah S, Khan YH, Mallhi TH. Arboviral diseases and COVID-19 coincidence: Challenges for Pakistan's derelict healthcare system. J Med Virol. 2021 Dec;93(12):6465-6467. doi: 10.1002/jmv.27241. Epub 2021 Aug 7. PMID: 34324213; PMCID: PMC8427066.
  29. Qamar MU, Rizwan M, Uppal R, Khan AA, Saeed U, Ahmad K, Iqbal MJ, Ali Z, Suleman M. Antimicrobial susceptibility and clinical characteristics of multidrug-resistant polymicrobial infections in Pakistan, a retrospective study 2019-2021. Future Microbiol. 2023 Oct 26. doi: 10.2217/fmb-2023-0110. Epub ahead of print. PMID: 37882773.
  30. Polaris Observatory Collaborators. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study. Lancet Gastroenterol Hepatol. 2023 Oct;8(10):879-907. doi: 10.1016/S2468-1253(23)00197-8. Epub 2023 Jul 27. PMID: 37517414.
  31. Piracha ZZ, Saeed U, Ahmed RA, Khan FN, Nasir MI. Global emergence of Langya virus: A serious public health concern. J Glob Health. 2023 Jul 7; 13:03034. doi: 10.7189/jogh-13-03034. PMID: 37411008; PMCID: PMC10325733.
  32. National Institute for Health and Care Research Global Health Research Unit on Global Surgery. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries. Br J Surg. 2023 Jun 12;110(7):804-817. doi: 10.1093/bjs/znad092. Erratum in: Br J Surg. 2023 Sep 22; PMID: 37079880; PMCID: PMC10364528.
  33. Saeed U, Piracha ZZ. PIN1 and PIN4 inhibition viaparvulin impeders Juglone, PiB, ATRA, 6,7,4'-THIF, KPT6566, and EGCG thwarted hepatitis B virus replication. Front Microbiol. 2023 Jan 25; 14:921653. doi: 10.3389/fmicb.2023.921653. PMID: 36760500; PMCID: PMC9905731.
  34. Global Burden of Disease 2021 Health Financing Collaborator Network. Global investments in pandemic preparedness and COVID-19: development assistance and domestic spending on health between 1990 and 2026. Lancet Glob Health. 2023 Mar; 11(3):e385-e413. doi: 10.1016/S2214-109X(23)00007-4. Epub 2023 Jan 24. PMID: 36706770; PMCID: PMC9998276.
  35. GBD 2019 Pakistan Collaborators. The state of health in Pakistan and its provinces and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob Health. 2023 Feb; 11(2):e229-e243. doi: 10.1016/S2214-109X(22)00497-1. PMID: 36669807; PMCID: PMC10009760.
  36. Nejadghaderi SA, Moghaddam SS, Azadnajafabad S, Rezaei N, Rezaei N, Tavangar SM, Jamshidi H, Mokdad AH, Naghavi M, Farzadfar F, Larijani B; GBD 2019 NAME Thyroid Cancer Collaborators. Burden of thyroid cancer in North Africa and Middle East 1990-2019. Front Oncol. 2022 Sep 23; 12:955358. doi: 10.3389/fonc.2022.955358. Erratum in: Front Oncol. 2023 Apr 28; 13:1208646. PMID: 36212501; PMCID: PMC9538696.
  37. Saeed U, Piracha ZZ, Uppal SR, Waheed Y, Uppal R. SARS-CoV-2 induced hepatic injuries and liver complications. Front Cell Infect Microbiol. 2022 Sep 16; 12:726263. doi: 10.3389/fcimb.2022.726263. PMID: 36189356; PMCID: PMC9523111.
  38. GBD 2019 LRI Collaborators. Age-sex differences in the global burden of lower respiratory infections and risk factors, 1990-2019: results from the Global Burden of Disease Study 2019. Lancet Infect Dis. 2022 Nov;22(11):1626-1647. doi: 10.1016/S1473-3099(22)00510-2. Epub 2022 Aug 11. PMID: 35964613; PMCID: PMC9605880.
  39. Khalid K, Saeed U, Aljuaid M, Ali MI, Anjum A, Waheed Y. Immunoinformatic Approach to Contrive a Next Generation Multi-Epitope Vaccine Against Achromobacter xylosoxidans Front Med (Lausanne). 2022 Jul 11; 9:902611. doi: 10.3389/fmed.2022.902611. PMID: 35899213; PMCID: PMC9309517.
  40. Polaris Observatory HCV Collaborators. Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study. Lancet Gastroenterol Hepatol. 2022 May;7(5):396-415. doi: 10.1016/S2468-1253(21)00472-6. Epub 2022 Feb 16. PMID: 35180382.
  41. Saeed U, Piracha ZZ, Kwon H, Kim J, Kalsoom F, Chwae YJ, Park S, Shin HJ, Lee HW, Lim JH, Kim K. The HBV Core Protein and Core Particle Both Bind to the PPiase Par14 and Par17 to Enhance Their Stabilities and HBV Replication. Front Microbiol. 2021 Dec 14; 12:795047. doi: 10.3389/fmicb.2021.795047. PMID: 34970249; PMCID: PMC8713550.
  42. Saeed U, Uppal SR, Piracha ZZ, Uppal R. SARS-CoV-2 Spike Antibody Levels Trend among Sinopharm Vaccinated People. Iran J Public Health. 2021 Jul;50(7):1486-1487. doi: 10.18502/ijph.v50i7.6640. PMID: 34568189; PMCID: PMC8426791.
  43. Saeed U, Kim J, Piracha ZZ, Kwon H, Jung J, Chwae YJ, Park S, Shin HJ, Kim K. Parvulin 14 and Parvulin 17 Bind to HBx and cccDNA and Upregulate Hepatitis B Virus Replication from cccDNA to Virion in an HBx-Dependent Manner. J Virol. 2019 Mar 5; 93(6):e01840-18. doi: 10.1128/JVI.01840-18. PMID: 30567987; PMCID: PMC6401437.
  44. Piracha ZZ, Kwon H, Saeed U, Kim J, Jung J, Chwae YJ, Park S, Shin HJ, Kim K. Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis through the AKT/GSK-3β/β-Catenin Signaling Pathway. J Virol. 2018 Oct 12; 92(21):e00955-18. doi: 10.1128/JVI.00955-18. PMID: 30111572; PMCID: PMC6189494.
  45. Saeed U, Waheed Y, Ashraf M, Waheed U, Anjum S, Afzal MS. Estimation of Hepatitis B Virus, Hepatitis C Virus, and Different Clinical Parameters in the Thalassemic Population of Capital Twin Cities of Pakistan. Virology (Auckl). 2015 Nov 5; 6:11-6. doi: 10.4137/VRT.S31744. PMID: 26568681; PMCID: PMC4636113.
  46. Waheed Y, Saeed U, Anjum S, Afzal MS, Ashraf M. Development of Global Consensus Sequence and Analysis of Highly Conserved Domains of the HCV NS5B Prote in. Hepat Mon. 2012 Sep; 12(9):e6142. doi: 10.5812/hepatmon.6142. Epub 2012 Sep 25. PMID: 23087757; PMCID: PMC3475062.
  47. Safi SZ, Waheed Y, Sadat J, Solat-Ul-Islam, Salahuddin S, Saeed U, Ashraf M. Molecular study of HCV detection, genotypes and their routes of transmission in North West Frontier Province, Pakistan. Asian Pac J Trop Biomed. 2012 Jul;2(7):532-6. doi: 10.1016/S2221-1691(12)60091-4. PMID: 23569965; PMCID: PMC3609335.

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